Wang. P. #, Yao, S. #, Kosami, K., Zhang, Y., Fukao, Y., Zhang, H., She, Y.M., Hanada, K., Liu, R.*, and Kawano, Y. * (2019) Identification of endogenous small peptides involved in rice immunity through transcriptomics- and proteomics-based screening. Plant Biotechnology Journal 2019 doi: 10.1111/pbi.13208
#: equally contributed, *: co-corresponding author


Wang, Q. #, Li, L. #, Ishikawa, K., Kosami, K., Uno, K., Nagawa, S., Tan, L., Du, J., Shimamoto, K., and Kawano, Y. (2018) Tesistance protein Pit interacts with the GEF OsSPK1 to activate OsRac1 and trigger rice immunity. PNAS 115(49):E11551-E11560
#: equally contributed

Xie Y., Zhang Y., Han J., Luo J., Li G., Huang J., Wu H., Tian Q., Zhu Q., Chen Y., Kawano, Y., Liu Y.-G., and Chen L. (2018) The Intronic cis-Element SE1 Recruits trans- acting Repressor Complexes to Repress the Expression of ELONGATED UPPERMOST INTERNODE1 in Rice. Mol. Plant. doi: 10.1016/j.molp.2018.03.001.

Wong, HL.#, Akamatsu, A.#, Wang, Q.#, Higuchi, M., Matsuda, T., Okuda, J., Kosami, K., Inada, N., Kawasaki, T., Nagawa, S., Tan, L., Kawano, Y. (corresponding author), Shimamoto, K. (2018) In vivo monitoring of plant small GTPase activation using a Förster resonance energy transfer biosensor Plant Methods 14:56
#: equally contributed


Nagano,M., Ishikawa, T., Fujiwara, M., Fukao, Y., Kawano, Y., Kawai-Yamada, M., and Shimamoto, K. (2016) Plasma membrane microdomains are essential for OsRac1-OsRbohB/H-mediated immunity in rice. Plant Cell 28:1966-83

Akamatsu, A., Shimamoto, K., and Kawano, Y. (2016) Crosstalk of Signaling Mechanisms Involved in Host Defense and Symbiosis against Microorganisms in Rice. Curr Genomic 17:1-17
Selected as a Editors' choice


Akamatsu, A., Uno, K., Kato, M., Wong, HL., Shimamoto, K., and Kawano, Y. (2015) New insights into the dimerization of small GTPase Rac/ROP guanine nucleotide exchange factors in rice. Plant Signal Behav 10:e1044702

Liu, L., Park, CH., He, F., Nagano, M., Wang, M., Bellizzi, M., Zeng, X., Liu, W., Ning, Y., Kawano, Y., and Wang, GL. (2015) The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice. PLoS Pathog 11:e1004629.
Selected in Tenth Anniversary PLOS Pathogens Collection


Kawano, Y. (Corresponding author), Fujiwara, T., Yao, A., Housen, Y., Hayashi, K., and Shimamoto, K. (2014) Palmitoylation-dependent membrane localization of the rice R protein Pit is critical for the activation of the small GTPase OsRac1. J Biol Chem 289:19079-88

Kawano, Y. (Corresponding author), Kawano-Kaneko, T., and Shimamoto, K. (2014) Rho family GTPase-dependent immunity in plants and animals. Front. Plant Sci 5:522

Cesari, S., Kanzaki, H., Fujiwara, T., Bernoux, M., Chalvon, V., Kawano, Y., Shimamoto, K., Dodds, P., Terauchi, R. Kroj, T. (2014) The NB-LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance. EMBO J 33:1941-59

Kosami, K, Ohki, I., Nagano,M., Furuita, K., Sugiki, T., Kawano, Y., Kawasaki,Y., Fujiwara, T., Nakagawa, A., Shimamoto, K., and Kojima, C. (2014) The crystal structure of the plant small GTPase OsRac1 reveals its mode of binding to NADPH oxidase. J Biol Chem 289:28569-78
Selected as a cover photo of JBC

Sakane, H., Horii, Y, Nogami, S., Kawano, Y., Kaneko-Kawano, T., and Shirataki, H. (2014) α-Taxilin forms a complex with sorting nexin 4 and participates in the recycling pathway of transferrin receptor. PLoS One 9: e93509


Kawano, Y., and Shimamoto, K. (2013) Early signaling network in rice PRR- and R-mediated immunity. Curr Opin Plant Biol. 16:496-504

Dang, TT. Shimatani, Z., Kawano, Y. (Corresponding author), Terada, R and Shimamoto, K. (2013) Gene editing a constitutively active OsRac1 by homologous recombination-based gene targeting induces immune responses in rice. Plant Cell Physiol 54:2058-2070

Akamatsu, A., Wong, H., Fujiwara, M., Okuda, J., Nishide, K., Uno, K., Imai, K., Umemura, K., Kawasaki, T., Kawano, Y., and Shimamoto, K. (2013) An OsCEBiP/OsCERK1-OsRacGEF1-OsRac1 module is an essential component of chitin-induced rice immunity. Cell Host Microbe 13: 465-476


Kim, S. H., Oikawa, T., Kyozuka, J., Wong, H. L., Umemura, K., Kishi-Kaboshi, M., Takahashi, A., Kawano, Y., Kawasaki, T., and Shimamoto, K. (2012) The bHLH Rac immunity1 (RAI1) is activated by OsRac1 via OsMAPK3 and OsMAPK6 in rice immunity. Plant Cell Physiol 53:740-754

Wamaitha, M., Yamamoto, R., Wong, H., Kawasaki, T., Kawano, Y., and Shimamoto, K. (2012) OsRap2.6 transcription factor contributes to rice innate immunity through its interaction with Receptor for Activated Kinase-C 1 (RACK1). Rice 5:35

Kaneko-Kawano, T., Takasu, F., Naoki, H., Sakumura, Y., Ishii, S., Ueba, T., Eiyama, A., Okada, A., Kawano, Y., and Suzuki, K. (2012) Dynamic regulation of myosin light chain phosphorylation by Rho-kinase. PLoS One 7:e39269

Horii, Y., Nogami, S., Kawano, Y., Kaneko-Kawano, T., Ohtomo, N., Tomiya, T., and Shirataki, H. (2012) Interaction of alpha-taxilin localized on intracellular components with the microtubule cytoskeleton. Cell Struct Funct 37:111-126


Kawano, Y., Akamatsu, A., Hayashi, K., Housen, Y., Okuda, J., Yao, A., Nakashima, A., Takahashi, H., Yoshida, H., Wong, H. L., Kawasaki, T., and Shimamoto, K. (2010a) Activation of a Rac GTPase by the NLR family disease resistance protein Pit plays a critical role in rice innate immunity. Cell Host Microbe 7:362-375

Kawano, Y., Chen, L., and Shimamoto, K. (2010b) The function of Rac small GTPase and associated proteins in rice innate immunity. Rice 3:112-121


Kawasaki T., Imai K., Wong H., Kawano Y., Nishide K., Okuda J., and Shimamoto K.. Rice guanine nucleotide exchange factors for small GTPase OsRac1 involved in innate immunity of rice. In Advances in Genetics, Genomics and Control of Rice Blast Disease. 179-184:2009


Yoshimura, T., Arimura, N., Kawano, Y., Kawabata, S., Wang, S., and Kaibuchi, K. (2006) Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway. Biochem Biophys Res Commun 340:62-68


Kawano, Y., Yoshimura, T., Tsuboi, D., Kawabata, S., Kaneko-Kawano, T., Shirataki, H., Takenawa, T., and Kaibuchi, K. (2005) CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol 25:9920-9935

Kawano, Y., Kaneko, T., Yoshimura, T., Kawabata, S., and Kaibuchi, K. (2005) RhoA/C and the Actin Cytoskeleton. RHO Family GTPases:113-136

Yoshimura, T., Kawano, Y., Arimura, N., Kawabata, S., Kikuchi, A., and Kaibuchi, K. (2005) GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell 120:137-149

Arimura, N., Menager, C., Kawano, Y., Yoshimura, T., Kawabata, S., Hattori, A., Fukata, Y., Amano, M., Goshima, Y., Inagaki, M., Morone, N., Usukura, J., and Kaibuchi, K. (2005) Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol 25:9973-9984

Kaneko, T., Maeda, A., Takefuji, M., Aoyama, H., Nakayama, M., Kawabata, S., Kawano, Y., Iwamatsu, A., Amano, M., and Kaibuchi, K. (2005) Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase. Genes Cells 10, 973-98


Kawano, Y., Yoshimura, T., and Kaibuchi, K. (2002) Smooth muscle contraction by small GTPase Rho. Nagoya J Med Sci 65:1-8


Inagaki, N., Chihara, K., Arimura, N., Menager, C., Kawano, Y., Matsuo, N., Nishimura, T., Amano, M., and Kaibuchi, K. (2001) CRMP-2 induces axons in cultured hippocampal neurons. Nat Neurosci 4:781-782


Kandabashi, T., Shimokawa, H., Miyata, K., Kunihiro, I., Kawano, Y., Fukata, Y., Higo, T., Egashira, K., Takahashi, S., Kaibuchi, K., and Takeshita, A. (2000) Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta. Circulation 101:1319-1323


Kawano, Y., Fukata, Y., Oshiro, N., Amano, M., Nakamura, T., Ito, M., Matsumura, F., Inagaki, M., and Kaibuchi, K. (1999) Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol 147, 1023-1038

Fukata, Y., Oshiro, N., Kinoshita, N., Kawano, Y., Matsuoka, Y., Bennett, V., Matsuura, Y., and Kaibuchi, K. (1999) Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol 145:347-361

Yamamoto, T., Harada, N., Kawano, Y., Taya, S., and Kaibuchi, K. (1999) In vivo interaction of AF-6 with activated Ras and ZO-1. Biochem Biophys Res Commun 259:103-107


Taya, S., Yamamoto, T., Kano, K., Kawano, Y., Iwamatsu, A., Tsuchiya, T., Tanaka, K., Kanai-Azuma, M., Wood, S. A., Mattick, J. S., and Kaibuchi, K. (1998) The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J Cell Biol 142:1053-1062


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河野 洋治(分担)、町田 泰則 (監修)、 岡田 清孝 (監修)、 山本 興太朗 (監修) 高校生物解説書 授業でそのまま使えるPowerPoint付き! 植物編, 2014
河野 洋治、島本 功: 植物免疫受容体の最前線 GTP結合タンパク質OsRac1を中心として 細胞工学 29(10): 1030-1034, 2010
河野 洋治、島本 功: 低分子量Gタンパク質Rac/Ropファミリーによる植物免疫の制御機構 共立出版, 99-104, 2010
河野 洋治、貝淵 弘三: 神経細胞の極性と軸索形成 医学のあゆみ 212(10):869-874, 2005
河野 洋治、吉村 武、貝淵 弘三: 低分子量GTP結合蛋白質Rhoと循環器疾患 日本薬理学雑誌 120(3):149-158, 2002
河野 洋治、深田 優子、貝淵 弘三:低分子量GTP結合蛋白質Rhoによる血管平滑筋の収縮機構 実験医学 5: 58-64, 2000


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